26 Colon Cancer
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Polyps
Hyperplastic
Adenomatous
- left: sessile
- right: pedunculated
- villi projection
- dysplastic cells
Polyp Symptoms
- pts with polyp > 1cm in diameter and numbers are at increased risks of developing metachronous
- more screening
Juvenile
- no dysplasia
- fall off and bleed, iron deficiency anemia
Peutz-Jeghers
- present with spots around lips and polyps
Genetics of Colon Cancer
- aspirin to prevent colon cancer
Chromosomal Instability
- cell mutated to have APC
- surrounding copies also have mutated APC
FAP
- born with entire colon have APC mutation
Gardner
- bumps all over body
- bump at jaw
- children born with dark spot
Turcot
Microsatellite
- separate from bulk of genetic material (satellites)
HNPCC
COX 2
DCC
Colon Cancer
- right side: bleed slowly, anemia
- exophytic: grow out from the side, does not obstruct stool, symptoms from bleeding
CEA
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